The Seton College Community was formed in God's name by the Daughters of Charity of St Elizabeth Ann Seton in 1964. Mother Seton was the first native-born American to be canonised (1975) by the Catholic Church. Founding the Sisters of Charity in 1809, she was dedicated to service in the charism of St Vincent de Paul. Her commitment to the care and education of children saw her establish the first free Catholic school in the United States, the beginning of a legacy which has since seen hundreds of thousands of children worldwide educated in her name by the Sisters and Daughters of Charity.
Father Denis Power, Parish Priest of St Paul's, East Mt Gravatt was instrumental in the establishment of the College in 1964. Sr Brigid Coakley of the Daughters of Charity was Seton's co-founder and first Principal.